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N = 488
Univariate analysis
Multivariate analysis
Factor
P value
Co-ef +/− SD
P value
Age
0.246*
0.925
Gender
0.012*
0.129
Pathology
Benign vs. Primary
0.442
0.144
Primary vs. Secondary
0.226*
0.878
Liver-directed chemotherapy
0.129*
0.219
Open or laparoscopic resection
0.009*
0.611
Radiofrequency ablation
0.191*
0.402
Wedge resection included
<0.001*
0.086
Bile duct reconstruction
0.004*
0.651
Number of segments resected
<0.001*
0.143 ± 0.012
<0.001†
Synchronous bowel procedure
0.516
Surgeon’s assessment of liver
<0.001*
0.185 ± 0.042
<0.001†
Redo operation
1st vs. 2nd resection
0.268
2nd vs. 3rd resection
0.654
Pre-operative diabetes
<0.001*
0.204 ± 0.064
0.002†
Body mass index
0.06*
0.905
ASA grade
1 vs. 2
0.014*
0.824
2 vs. 3
0.709
0.872
P-POSSUM physiologic score
0.054*
0.221
Hepatic fibrosis/cirrhosis
0.667
Pre-operative bilirubin
0.320
Pre-operative haemoglobin
0.633
Neutrophil:lymphocyte ratio
0.400
Pre-operative albumin
0.399
Pre-operative alkaline phosphatase
0.014*
0.775
Pre-operative creatinine
0.392
Pre-operative glomerular filtration rate (GFR) >90 ml/min
0.042*
0.054
Blood loss (ml)
<500 vs. 500-999
<0.001*
0.131 ± 0.038
0.013†
500-999 vs. >1000
0.435
0.884
Units of red cells transfused
<0.001*
0.043 ± 0.011
<0.001†
*Significant at the level of 0.25 for univariate analysis and included in multivariate analysis; †significant at the level of 0.05 for multivariate analysis.
