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| |
Bridging group
|
Control group
|
p value1
|
|---|
|
n
|
263
|
263
| |
|
Age [years]
|
71 ± 10
|
71 ± 10
|
0.63
|
|
Sex [male, %]
|
63.5%
|
62.4%
|
0.86
|
|
Body mass index [kg/m2]
|
27 ± 5
|
27 ± 11
|
0.89
|
|
ASA physical status classification system > 2 [n, %]
|
207 (79%)
|
117 (44%)
|
< 0.001
|
|
Bridging indications
|
Atrial fibrillation [n, %]
|
217 (82%)
|
–
| |
|
Past thromboembolic events [n, %]
|
31 (12%)
|
–
|
|
Heart valve replacement [n, %]
|
22 (9%)
|
–
|
|
Thrombophilia [n, %]
|
9 (3%)
|
–
|
|
Risk of thromboembolism
|
Low [n, %]
|
136 (52%)
|
100%
|
< 0.001
|
|
Moderate [n, %]
|
75 (28%)
|
–
|
|
High [n, %]
|
52 (20%)
|
–
|
|
Risk of bleeding
|
HAS-BLED score
|
2.6 ± 1.0
|
2.2 ± 1.2
|
< 0.001
|
|
High bleeding risk (HAS-BLED score > 2) [n, %]
|
46 (18%)
|
31 (12%)
|
0.11
|
|
Procedure-specific risk of bleeding
|
Minimal (category 1) [n, %]
|
0
|
0
|
0.62
|
|
Mild (category 2) [n, %]
|
121 (46%)
|
116 (44%)
|
|
Moderate (category 3) [n, %]
|
90 (34%)
|
101 (38%)
|
|
Major (category 4) [n, %]
|
40 (15%)
|
32 (12%)
|
|
Critical (category 5) [n, %]
|
12 (5%)
|
14 (5%)
|
|
Cardiovascular risk factors
|
Hypertension: blood pressure consistently above 140/90 mmHg or treated with hypertension medication [n, %]
|
219 (83%)
|
162 (62%)
|
< 0.001
|
|
Congestive heart failure [n, %]
|
88 (33%)
|
18 (7%)
|
< 0.001
|
|
Coronary heart disease/arterial occlusive disease [n, %]
|
89 (34%)
|
44 (17%)
|
< 0.001
|
|
Chronic renal insufficiency ≥ stage III (GFR < 60 ml/min) [n, %]
|
97 (37%)
|
36 (14%)
|
< 0.001
|
|
Diabetes mellitus [n, %]
|
79 (30%)
|
47 (18%)
|
0.001
|
- 1p values of continuous outcomes were calculated by a two-sided two-sample t test assuming equal variances; p values of categorical outcomes were calculated by a two-sided χ2 test or, in case of categories with less than 5 subjects, by Fisher’s exact test
