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Table 4 Risk factors of major postoperative bleeding

From: Markedly increased risk of postoperative bleeding complications during perioperative bridging anticoagulation in general and visceral surgery

  p value univariate p value multivariate Odds ratio (95% CI)
Procedure-specific risk of bleeding 0.003 0.008 1.8 (1.2–2.9)
HAS-BLED score 0.31   
Malignant tumor 0.52   
Age > 65 years 0.084   
Arterial hypertension 0.041   
Congestive heart failure 0.039   
Renal insufficiency (GFR < 60) < 0.0001 < 0.0001 5.8 (2.3–14.6)
Hemoglobin level 0.82   
International normalized ratio (INR) 0.072   
Platelet count 0.77   
Perioperative bridging < 0.0001   
Full-therapeutic dose of LMWH < 0.0001 < 0.0001 18.7 (3.6–95)
Preoperative interruption of LMWH ≤ 24 h 0.007   
Postoperative interruption of LMWH ≤ 24 h 0.006 0.068 1.5 (0.9–2.2)